Reviewed and written by Martin Ebner, certified personal trainer.
Formula and evidence last checked October 2026.
Performance Lab Immune used to be called PL-Immune. The name has changed, the formula has been adjusted and my original review had become far more confident than the evidence deserved.
It was written during the pandemic, when almost every immune supplement was being sold like an invisible suit of armour. I gave this one 9/10 and suggested that not getting ill probably meant it was working. Looking back, that was too generous and far too easy.
If I take a capsule and don’t catch a cold, it doesn’t prove the capsule stopped one. If I do catch a cold, it doesn’t prove the formula is useless. Immune health is complicated, so this review gives the product a fairer and considerably more useful assessment.
THE QUICK VERDICT
Performance Lab Immune is a thoughtfully formulated immune-support supplement. It combines moderate amounts of vitamin D, vitamin C, zinc and selenium with LC-Plasma and glutathione, provides every dosage openly and requires only one capsule per day.
The formula makes sense, but some of the marketing gets ahead of what the evidence can establish. The individual nutrients support normal immune function, particularly when somebody isn’t getting enough of them. That doesn’t prove this finished supplement will prevent colds, flu or anything else waiting to ruin your week.
At $34 for 30 capsules, it’s better value than it used to be. I’d consider it during winter, frequent travel or a particularly demanding period, provided I wasn’t already duplicating the same nutrients through a multivitamin.
My score: 7/10.
Use code EXTRA10 at checkout for 10% off.
PERFORMANCE LAB IMMUNE AT A GLANCE
Current name: Performance Lab Immune v1
Previous name: Performance Lab PL-Immune
Price when reviewed: $34 for a one-time purchase
Serving size: One capsule
Servings per bottle: 30
Suitable for vegans: Yes
Caffeine-free: Yes
Main ingredients: LC-Plasma, glutathione, vitamin D3, vitamin C, zinc and selenium
Best suited to: People wanting convenient nutritional support during winter, travel or demanding periods
Probably unnecessary for: Anyone already taking a comprehensive multivitamin containing the same nutrients
My score: 7/10
WHAT IS PERFORMANCE LAB IMMUNE?
Performance Lab Immune is a once-daily supplement designed to support normal immune function. It combines four familiar micronutrients with two more unusual ingredients, LC-Plasma and glutathione.
This isn’t a completely new product. It’s the updated version of PL-Immune, with revised branding, a lower current price and a reduction in LC-Plasma from 50 mg to 36 mg.
The capsules are vegan, the full formula is disclosed and there’s no proprietary blend hiding the individual amounts. Performance Lab also says the product is independently tested for purity and potency.
What it can’t do is make you invincible. Your immune system isn’t a volume dial that can be turned all the way up, and a supplement can’t remove your need for decent food, sleep, exercise and recovery.
WHAT’S IN THE CURRENT FORMULA?
Each capsule currently provides:
Vitamin D3: 25 mcg, or 1,000 IU
Vitamin C: 30 mg
Selenium: 25 mcg
Zinc: 5 mg
Lactococcus lactis strain Plasma, or IMMUSE LC-Plasma: 36 mg
Setria glutathione: 250 mg
The amounts are sensible rather than enormous. That’s mostly a positive, although it also means people should keep their expectations in proportion.
LC-PLASMA
LC-Plasma is the ingredient that separates Performance Lab Immune from an ordinary vitamin and mineral supplement.
It’s a heat-treated strain of Lactococcus lactis, which makes it a postbiotic rather than the sort of live probiotic you might find in yogurt. Research suggests it can interact with plasmacytoid dendritic cells, which play a role in coordinating parts of the immune response.
A randomised controlled trial involving Vietnamese schoolchildren found fewer days absent through upper-respiratory or gastrointestinal illness among those consuming LC-Plasma. That’s interesting, but it needs context. The study involved children, used a beverage rather than Performance Lab Immune and had involvement from the ingredient manufacturer.
Other studies have examined immune markers and respiratory symptoms, but they don’t prove that this exact finished capsule prevents illness in healthy adults.
LC-Plasma gives the formula a legitimate point of difference. I simply wouldn’t stretch the evidence far enough to call it protection against colds or flu.
GLUTATHIONE
Glutathione is an antioxidant produced naturally inside the body. It helps cells deal with oxidative stress and has an important relationship with immune function.
Performance Lab uses 250 mg of Setria glutathione. There’s human research showing that oral glutathione can influence glutathione levels and certain immune markers, although the studies are generally small and don’t all use the same form or amount found here.
Calling glutathione the body’s “master antioxidant” sounds wonderful on a product page. It doesn’t automatically mean taking more will make a healthy person noticeably healthier.
I see it as a potentially useful part of the formula rather than a reason to buy the product on its own.
VITAMIN D, VITAMIN C, ZINC AND SELENIUM
These four nutrients all contribute to normal immune function. Deficiencies can weaken that function, so getting enough genuinely matters.
The National Institutes of Health review of supplements and immune function reaches a much less exciting conclusion than most supplement advertising. Correcting an inadequate intake can be useful, but taking more nutrients when you already have enough doesn’t necessarily provide additional protection.
The 25 mcg of vitamin D3 is the strongest part of this micronutrient blend. It’s a sensible daily amount, particularly for somebody with limited sunlight exposure or a low dietary intake. Evidence around vitamin D and respiratory infections is mixed, with the clearest reason to supplement remaining the prevention or correction of deficiency.
The 30 mg of vitamin C supports normal immune function but isn’t a large dose. Regular vitamin C supplementation may slightly shorten a cold, although it generally doesn’t stop healthy adults from catching one.
The zinc and selenium amounts are modest. That reduces the risk of turning a daily immune supplement into a megadose, but it also means they’re there to support your overall intake rather than produce a dramatic effect.
If vitamin D is your main concern, my guide to taking vitamin D3 and K2 together gives you a more focused look at the evidence.
DOES IT ACTIVATE FIVE TYPES OF IMMUNE CELLS?
Performance Lab says Immune activates or enhances plasmacytoid dendritic cells, natural killer cells, killer T cells, helper T cells and B cells.
There’s a biological basis for connecting LC-Plasma with parts of that immune response. The problem is how easily a complicated process becomes a wonderfully simple marketing line.
An ingredient affecting an immune pathway in research doesn’t prove that taking this capsule gives you five stronger types of immune cell or makes you five times better protected against illness. It certainly doesn’t mean you’ll feel those cells springing into action after breakfast.
The claim isn’t plucked from nowhere, but it makes the outcome sound more certain and measurable than it really is.
CAN PERFORMANCE LAB IMMUNE STOP YOU GETTING ILL?
No supplement can promise that.
Immune function depends on your nutritional status, sleep, stress, physical activity, age, health, exposure to infection and plenty of other things that don’t fit neatly onto a supplement label.
Performance Lab Immune may help cover certain nutritional gaps. LC-Plasma and glutathione also make it more interesting than simply combining vitamin C and zinc in a capsule.
That gives it a credible role in supporting normal immune function. It doesn’t make it a treatment, cure or guarantee against catching whatever is currently doing the rounds.
WHAT CAN YOU EXPECT TO FEEL?
Probably nothing dramatic.
This isn’t caffeine, a pre-workout or a sleeping tablet. There shouldn’t be an obvious moment when it kicks in.
That makes personal experience particularly difficult to judge. If you take it for three months and remain healthy, you can’t know what would have happened without it. The same applies if you catch a cold after two weeks.
You might appreciate the reassurance of covering several immune-related nutrients with one capsule. That has value, particularly when travel, work or life makes your usual diet less reliable. It just shouldn’t be confused with proof that the supplement prevented an illness.
IS IT BETTER THAN A MULTIVITAMIN?
It depends on what you need.
Performance Lab Immune is more targeted. It includes LC-Plasma and glutathione, which aren’t present in Performance Lab Multi, and it requires only one capsule per day.
Performance Lab Multi covers a much broader range of vitamins and minerals. It already contains vitamin C, vitamin D, zinc and selenium in amounts equal to or greater than those found here.
I wouldn’t automatically take both. The combined amounts remain fairly moderate, but you’d be paying to duplicate several nutrients without knowing whether you needed more.
If your overall diet is inconsistent, read my Performance Lab Multi review. If your diet is generally good and you specifically want the LC-Plasma and glutathione combination, Immune is the more focused option.
HOW TO TAKE PERFORMANCE LAB IMMUNE
Performance Lab recommends taking one capsule every morning with food.
That’s refreshingly straightforward. There’s no complicated loading phase, no handful of capsules and no reason to keep increasing the serving.
Consistency makes more sense than taking it only when you already feel ill. The ingredients are intended to support normal function over time, not act as an emergency cold cure.
SIDE EFFECTS AND SAFETY
The vitamin and mineral amounts are moderate, and I wouldn’t expect most healthy adults to have a problem with the standard serving.
You should still check what’s in your other supplements. Multivitamins, vitamin D products and several recovery formulas may already contain vitamin D, zinc and selenium.
Anyone who is pregnant, breastfeeding, taking regular medication or managing an existing condition should check with a doctor or pharmacist before adding it. The same applies if you have an immune disorder or are undergoing treatment that affects immune function.
A supplement designed to support normal immunity isn’t a replacement for medical care when you’re actually unwell.
IS PERFORMANCE LAB IMMUNE GOOD VALUE?
The one-time price was $34 when I checked it in October 2026. That works out at roughly $1.13 per day.
Subscriptions reduce the monthly cost, although I’d start with one bottle before committing to repeat deliveries. Performance Lab also offers a 30-day money-back guarantee, subject to its current terms.
You can buy vitamin C, vitamin D or zinc for considerably less. The extra cost covers the LC-Plasma, glutathione, vegan capsule, quality testing and convenience of combining everything into one serving.
I think the current $34 price is reasonable for the formula. Whether it’s good value for you depends on whether you actually want the two specialist ingredients or simply need a basic vitamin supplement.
THE PROS
One capsule per day
Every active ingredient and dosage is disclosed
Moderate vitamin and mineral amounts
LC-Plasma gives the formula a genuine point of difference
Includes 25 mcg of vitamin D3
Vegan and free from several common allergens
No caffeine or proprietary blend
Independently tested for purity and potency
Thirty-day money-back guarantee
THE CONS
The complete finished formula hasn’t been tested in an independent clinical trial
Ingredient research doesn’t prove that the product prevents illness
Some LC-Plasma research has manufacturer involvement
The vitamin C amount is fairly modest
Several nutrients overlap with Performance Lab Multi
Benefits are difficult to feel or measure personally
It’s available only through Performance Lab
WHO SHOULD CONSIDER IT?
Performance Lab Immune makes the most sense if you want a simple, once-daily formula during winter, frequent travel or a particularly demanding period.
It may also suit somebody whose diet is generally decent but not perfectly consistent and who specifically wants LC-Plasma and glutathione alongside modest amounts of the main immune-related vitamins and minerals.
The clean formula, vegan capsule and clear dosages also make it more appealing than many immune supplements built around enormous vitamin doses and promises they can’t possibly keep.
WHO SHOULD SAVE THEIR MONEY?
If you already take Performance Lab Multi or another comprehensive multivitamin, much of the formula will overlap.
You probably don’t need it if your diet is varied, your vitamin D status is healthy and you’re expecting nothing more than basic nutritional support.
It’s also the wrong purchase if you want something that will stop an approaching cold, treat an infection or compensate for weeks of poor sleep and very little food resembling food.
MY FINAL VERDICT
Performance Lab Immune is better than my old review made it sound, although not for the same reasons.
It doesn’t deserve 9/10 for supposedly making the immune system bulletproof. No supplement can do that. It deserves credit for combining sensible vitamin and mineral amounts with two more distinctive ingredients in one convenient capsule.
LC-Plasma has promising human research behind it, but the evidence doesn’t prove this complete product prevents illness in healthy adults. Glutathione is interesting, although I wouldn’t buy the product for that ingredient alone. The micronutrients support a solid foundation without drifting into ridiculous dosages.
At $34, I think it’s a credible option for somebody who wants targeted immune support and isn’t already duplicating the formula through another supplement.
It isn’t essential, it isn’t body armour and it won’t make you immune to the person coughing beside you on the train. It is a clean, convenient and reasonably priced formula that may help cover a few useful bases.
My score: 7/10.
Use code EXTRA10 at checkout for 10% off.
RELATED REVIEWS
For broader nutritional cover, read my Performance Lab Multi review.
If sleep is the part of your routine falling apart, my Performance Lab Sleep review is more relevant.
If you’ve ever wondered whether you need an immune supplement or simply an earlier night and an orange, Check It Oot is where I sort through the evidence without pretending every new capsule belongs in your cupboard. One email once or twice a month, written by me and delivered straight to your inbox.
